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Well... I personally wouldn't ever cross two frame horses... ever. Hom frame is lethal (minus freaky Friday's), and it's not worth it to me. W2 is lethal with almost everything Kit, so I avoid it when possible. The ONLY time I accept W2 is if it's on a leopard foal I absolutely love. Then I'll keep it, because I can breed it out, GMT it off, or not worry too much because it's only mixed with appy. Frame, I'll happily breed. But I usually only keep mares with it, and ensure my stallions don't have it. My alt, YarbroughFarms, is actually breeding DP horses (mostly livers and chocolate palominos, but a few DP bays), and most of my 2g mares are splash frames. I love them. My foundation stallion is splash frame, liver. I won him in a contest, so I use him wisely, and with caution. My 2g stallion(s) must not be frame, due to the fact I have several frame mares.

My advice is to brush up on punnet squares. That way, you can figure out the chances of parents throwing lethal combinations. For example, when crossing two horses who are heterozygous frame, using a punnet square you would find that you will have a 25% chance of a horse with no frame, a 50% chance of a live heterozyous frame foal, and a 25% chance of frame lethality.

As for mixing Kit genes, I had a mini project going on for a while where I purposefully bred high lethality Kit genes together to see how high I could get the white factor before losing foals. I mainly used w1, w2, w3, and w10 (if you haven't come across one yet, Kitw3Kitw2 is a gorgeous combo). I didn't introduce much frame or splash, but I found that with just the risky Kit gene combination, I could get up to minimal or medium white factor without losing foals.

My suggestion is to keep either splash or frame out of your stallions, as those genes will increase white factor even more. Alternatively, come up with a good prefix or tattoo system so you know what mares and stallions not to mix (I would keep the splash and/or frame to one parent only).

In addition, only keep stallions with a white factor of minimal or none to keep the white patterning down in foals.

Good luck! I really enjoyed my "lethal project" and was sad when I had to sell off the line. Everyone loses foals in-game every once in a while, so don't feel bad about it.

I only have frame in my mares but I do have a lot of w1 and w2. I am actually focusing on improving my w1/8 line as my foals do well on the pt board for w1. Honestly I just throw them in a pasture and hope for the best. I used to take out the w1and 2 mares and breed them to a less risky stallion but I don't have the time or energy to do that any more.